Epidermal Changes in Human Skin Following Irradiation With Either UVB or UVA

UVA and UVB Irradiation Differentially Regulate microRNA Expression in Human Primary Keratinocytes

MicroRNA (miRNA)-mediated regulation of the cellular transcriptome is an important epigenetic mechanism for fine-tuning regulatory pathways. These include processes related to skin cancer development, progression and metastasis. However, little is known about the role of microRNA as an intermediary in the carcinogenic processes following exposure to UV-radiation. We now show that UV irradiation...

The UVB content of 'UVA fluorescent lamps' and its erythemal effectiveness in human skin.

The UVB emission from ten different types of 'UVA fluorescent lamp' has been measured by spectroradiometry. The mean ratio of UVB emission to UVA emission was found to be 0.94 +/- 0.35 (1 SD)%. By weighting the spectral irradiance of each lamp by the DIN standard erythemal curve, the mean erythemally effective UVB emission (normalised to 297 nm), expressed as a percentage of the UVA emission, w...

Histological findings in the Wistar rat cornea following UVB irradiation.

The acute clinical effect of UVR on the eye is photokeratitis, which is an inflammatory state that might be regarded as the sunburn of the eye. In this study, we used a rat model to assess the histological injuries induced in the intact rat cornea following its exposure to UVB radiation. A total of 15 two-months-old female Wistar rats were purchased from the Animal Facility of "Iuliu Hatieganu"...

Mitochondria-Targeted Vitamin E Protects Skin from UVB-Irradiation

Mitochondria-targeted vitamin E (MVE) is designed to accumulate within mitochondria and is applied to decrease mitochondrial oxidative damage. However, the protective effects of MVE in skin cells have not been identified. We investigated the protective effect of MVE against UVB in dermal fibroblasts and immortalized human keratinocyte cell line (HaCaT). In addition, we studied the wound-healing...

The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: A role for UVA in human skin